0
Knockout Cell Lines
Bring the precision of CRISPR gene-editing technology to your lab without the hassle
Advantages of Horizon’s gene-edited knockout cell lines:
- Complete loss of gene function
- Includes isogenic controls to confirm your results
- Over 2000 clonal cell lines available for immediate hypothesis testing
- Money back guarantee if you are not satisfied
Use the search bar at the top of the page to browse for your gene of interest, using the HUGO Gene Nomenclature. There are thousands of popular lines in stock – Your order could be delivered in only a few weeks!
> More information about Knockout Cell Lines
Knockin Cell Lines
Recapitulate or even correct disease phenotypes
Disease relevant mutations can be recapitulated or even correct by introducing a point mutation with a single base change, or by inserting/deleting large gene sequences. These endogenous knockin cell lines enable a clear understanding of the contribution of the gene or mutation to a phenotype, in contrast to overexpression models where high expression (either transiently or stably) can lead to false positives. Horizon produces rAAV and CRISPR knockin cell lines or a combination of both.
Use the search bar at the top of the page to browse for your gene of interest, using the HUGO Gene Nomenclature.
> More information about Knockin Cell Lines
Cell Line Engineering
Custom gene-edited cell lines with your chosen genotype
With nearly a decade of experience planning and executing nearly 3,000 gene editing experiments, access to a multiple genome editing technologies, and cell line development service options to suit a variety of experimental needs and budgets, Horizon is the global leader in cell line engineering.
- Strong IP position to support your freedom to operate
- Substantial experience with over 100 cell lines and 200 target genes
- Emphasis on design to test your hypothesis, not just project execution
- A collaborative approach including a dedicated project manager to ensure the project meets your needs
- Development of genomically validated isogenic cell line pairs (all cell lines are provided with a non-edited control)
- Initial characterization of parental cell line prior to gene-editing (if required)
> More information about Cell Line Engineering
Reporter Cell Lines
Accurately Track protein expression and localization in real-time at near physiological level
Horizon and Promega Corporation have partnered in a long-term relationship to develop a suite of best-in-class endogenous pathway tag and reporter cell lines for application in functional genomics research and drug discovery and development.
Gene-editing at the endogenous level allows researchers to examine near-physiological levels of protein and promoter activity. Traditional methods of understanding protein/promoter function have used exogenous plasmid-based over-expression systems which can result in artefactual results.
Our collection of ready-made cell lines with tags is growing. Alternatively, we can modify your specific cell line for you. To discuss design of your experiment or for more information on our reporter cell lines
> More information about Reporter Cell Lines
Ready Made Cell Lines
Start your project fast with our catalog gene-edited cell lines
Horizon’s isogenic human cell line pairs provide a model system for the study of the role of genes in cellular processes and drug responses. All cell lines are provided with a matched wild type control parental cell line ensuring phenotypes can be attributed directly to the requested genetic modification(s).
- Confidence – Each cell line is matched with an isogenic control to confirm your results
- Reliability – Highly characterized and quality controlled clonal human cell lines
- Convenience – Over 2500 edited cell lines in our catalog ready to be delivered within only a few weeks
Our catalog contains an expanding range of edited cell lines that include common cancer cell lines such as DLD1, MCF10 and HCT116, as well as our proprietary HAP1 cell line.